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Home Antibody All anti-NKIRAS2 antibodies

Anti-NKIRAS2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306085
  • Rabbit Polyclonal KappaB ras2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC425022) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for NKIRAS2 (NM_001001349)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenKappaB ras2 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human KappaB ras2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens NFKB inhibitor interacting Ras-like 2 (NKIRAS2), transcript variant 1
Alternative NamekappaB-Ras2; KBRAS2
Database LinkNP_001001349
Entrez Gene 28511 Human
Entrez Gene 71966 Mouse
Entrez Gene 287707 Rat
FunctionKappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KappaB ras2 in RAW264.7 cell lysate with KappaB ras1 antibody at 1 µg/ml in the (A) absence and (B) presence of blocking peptide.

 

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