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Home Antibody All anti-NKIRAS1 antibodies

Anti-NKIRAS1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306083
  • Rabbit Polyclonal KappaB ras Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412541) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NKIRAS1 (NM_020345)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenKappaB ras antibody was raised against a 18 amino acid peptide from near the center of human KappaB ras 1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1)
Alternative NamekappaB-Ras1; KBRAS1
Database LinkNP_065078
Entrez Gene 28512 Human
Entrez Gene 69721 Mouse
Entrez Gene 305751 Rat
FunctionKappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KappaB ras in 293 cell lysate with KappaB ras antibody at (A) 2 and (B) 4 ug/ml.
IHC Image
Immunohistochemistry of KappaB ras in human lymph node tissue with KappaB ras antibody at 1 ug/ml.

 

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