Home Antibody All anti-NKIRAS1 antibodies
Also for NKIRAS1 (NM_020345)
|KappaB ras antibody was raised against a 18 amino acid peptide from near the center of human KappaB ras 1.|
|Human, Mouse, Rat
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1)|
|KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.|
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Western blot analysis of KappaB ras in 293 cell lysate with KappaB ras antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry of KappaB ras in human lymph node tissue with KappaB ras antibody at 1 ug/ml.