Home Antibody All anti-NFKBIA antibodies
Also for NFKBIA (NM_020529)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 305 of Human NFKBIA|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)|
|IKBA; MAD-3; NFKBI|
|NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]|
Delta-Notch Signaling Pathway
Toll-like receptor signaling pathway
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Sample (30 ug of whole cell lysate) A: HepG2 (anti-NFKBIA antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using IkappaB-alpha(anti-NFKBIA antibody) antibody at 1:200 dilution.