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Home Antibody All anti-NFKBIA antibodies

Anti-NFKBIA Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308928
  • Rabbit polyclonal antibody to IkappaB-alpha (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412432) , 20ug
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for NFKBIA (NM_020529)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 305 of Human NFKBIA
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB:1:500-1:3000; IF:1:100-1:200;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)
Alternative NameIKBA; MAD-3; NFKBI
Database LinkNP_065390
FunctionNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
Related Pathway
Apoptosis
Delta-Notch Signaling Pathway
Toll-like receptor signaling pathway

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WB Image
Sample (30 ug of whole cell lysate) A: HepG2 (anti-NFKBIA antibody diluted at 1:1000)
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using IkappaB-alpha(anti-NFKBIA antibody) antibody at 1:200 dilution.

 

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