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Anti-NCLN Antibody Polyclonal


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  • Rabbit Polyclonal NCLN Antibody
100ug 325 In Stock
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OriGene Data

ImmunogenNCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 ug/ml, IHC: 2.5 ug/ml, IF: 2.5 ug/ml
BufferNCLN Antibody is supplied in PBS containing 0.02% sodium azide.
Purification NCLN Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens nicalin (NCLN)
Alternative NameNET59
Database LinkNP_064555
Entrez Gene 56926 Human
Entrez Gene 103425 Mouse
Entrez Gene 314648 Rat
FunctionNCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NCLN in mouse heart tissue lysate with NCLN antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of NCLN in human heart tissue with NCLN antibody at 2.5 ug/mL.
IF Image
Immunofluorescence of NCLN in human heart tissue with NCLN antibody at 20 ug/mL.


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