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Anti-NBN PHOSPHO Antibody EPR2470Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against p95 NBS1 Phospho (pS432) (clone EPR2470Y ) (Phospho-Specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding serine 432 of human p95/NSB1 was used as an immunogen. This antibody detects p95/NSB1 that is phosphorylated on serine 432.
Clone NameEPR2470Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens nibrin (NBN)
Alternative NameAT-V1; AT-V2; ATV; NBS; NBS1; P95
Database LinkNP_002476
Entrez Gene 4683 Human
FunctionNijmegen breakage syndrome (NBS) is characterized by extreme radiation sensitivity, chromosomal instability and cancer. p95/NBS1 is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. Phosphorylation of p95/NBS1 mediated by gamma-radiation, but not that induced by hydroxyurea or ultraviolet light, was markedly reduced in ATM cells. Phosphorylation of p95/NBS1 by ATM is critical for certain responses of human cells to DNA damage (1). p95/NBS1 is part of a protein complex that is involved in responses to DNA double-strand breaks. Observations link ATM and p95/NBS1 in a common signaling pathway and provide an explanation for phenotypic similarities in NBS and ATM diseases (2). Double-strand breaks occur during DNA replication and are also induced by ionizing radiation. NBS1 is essential for homologous recombination-mediated repair in higher vertebrate cells and the disruption of p95/NBS1 reduces gene conversion and sister chromatid exchanges (3).
Related PathwayDruggable Genome Homologous recombination

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WB Image
Western blot - p95 NBS1 (phospho S432) antibody [EPR2470Y]; All lanes : Anti-p95 NBS1 (phospho S432) antibody [EPR2470Y] at 1/500 dilution.Lane 1 : HeLa cell lysates, untreated.Lane 2 : HeLa cell lysates, treated with doxorubincin.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 85 kDa.Observed band size : 85 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p95 NBS1 (phospho S432) antibody [EPR2470Y]; TA307442 at 1/100-1/250 dilution staining p95 NBS1 in human testis by Immunohistochemistry, Paraffin-embedded tissue.


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