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Home Antibody All anti-NANOS1 antibodies

Anti-NANOS1 Antibody

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SKU Description Amount Price Availability*  
TA306605 Rabbit Polyclonal Nanos1 Antibody 100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenNanos1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Nanos1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nanos homolog 1 (Drosophila) (NANOS1)
Alternative NameNOS1; SPGF12
Database LinkNP_955631
Entrez Gene 340719 Human
FunctionNanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Nanos1 in SK-N-SH cell lysate with Nanos1 antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
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Immunohistochemistry of Nanos1 in human brain tissue with Nanos1 antibody at 2.5 ug/ml
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