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Home Antibody All anti-MYL3 antibodies

Anti-MYL3 Antibody EPR4161

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307729
  • Rabbit monoclonal antibody against Myosin Light Chain 3(clone EPR4161)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400098) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for MYL3 (NM_000258)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Myosin Light Chain 3 was used as an immunogen.
Clone NameEPR4161 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 22 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3)
Alternative NameCMH8; MLC1SB; MLC1V; VLC1
Database LinkNP_000249
Entrez Gene 4634 Human
Entrez Gene 17897 Mouse
Entrez Gene 24585 Rat
FunctionMyosin is a hexamer of 2 heavy chains and 4 light chains (1). The two pairs of light chains of muscle myosins are called essential light chains (ELC) and regulatory light chains (RLC). The light chains stabilize the long alpha helical neck of the myosin head (2). Myosin Light Chain 3 is an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform (3). In addition, it is a regulatory light chain of myosin that is involved in cardiac muscle contraction (1). However, it does not bind to calcium (1). Mutations in Myosin Light Chain 3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy (3).
Related PathwayDruggable Genome Cardiac muscle contractionHypertrophic cardiomyopathy (HCM)Dilated cardiomyopathy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Myosin light chain 3 antibody [EPR4161]; All lanes : Anti-Myosin light chain 3 antibody [EPR4161] at 1/1000 dilution.Lane 1 : Human skeletal muscle lysate.Lane 2 : Human heart lysate.Lane 3 : Mouse heart lysate.Lane 4 : Mouse liver lysate.Lane 5 : Rat heart lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 22 kDa.

 

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