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Home Antibody All anti-MYC antibodies

Anti-MYC Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA325703
  • Rabbit Polyclonal C-myc antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400876) , 20ug Explanation
100ul 325 3 Weeks
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WB(1)
IHC(1)
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Also for MYC (NM_002467)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthesized peptide derived from human C-myc
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1:2000; IHC: 1:50-1:200
BufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.

Reference Data

Target NameHomo sapiens v-myc avian myelocytomatosis viral oncogene homolog (MYC)
Alternative NamebHLHe39; c-Myc; MRTL; MYCC
Database LinkNP_002458
Entrez Gene 4609 Human
Entrez Gene 17869 Mouse
Entrez Gene 24577 Rat
FunctionMembers of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis . These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription.
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayStem cell relevant signaling - TGFb/BMP signaling pathwayStem cell relevant signaling - Wnt Signaling pathwayStem cell - PluripotencyEmbryonic stem cellsInduced pluripotent stem cellsTranscription FactorsDruggable Genome MAPK signaling pathwayErbB signaling pathwayCell cycleWnt signaling pathwayTGF-beta signaling pathwayJak-STAT signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of extracts from HuvEc cells, using MYC Antibody. The lane on the right is treated with the synthesized peptide.
IHC Image
Immunohistochemistry analysis of paraffin- embedded human lung carcinoma tissue, using MYC Antibody.

 

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