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Home Antibody All anti-MSR1 antibodies

Anti-MSR1 TRUEMAB Antibody Clone OTI9B8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA802827 MSR1 mouse monoclonal antibody, clone OTI9B8 (formerly 9B8) 100ul $325 In Stock
LC408527 MSR1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF802827 Carrier-free (BSA/glycerol-free) MSR1 mouse monoclonal antibody, clone OTI9B8 (formerly 9B8) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 197-451 of human MSR1(NP_619730) produced in E.coli.
Clone NameClone OTI9B8 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000,
Predicted MW Explanation 42.8 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII
Alternative NameCD204; phSR1; phSR2; SCARA1; SR-A; SRA
Database LinkNP_619730
Entrez Gene 4481 Human
FunctionThis gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008].
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSR1 (RC223314, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSR1.
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-MSR1 mouse monoclonal antibody. (TA802827) Dilution: 1:150
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