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Home Antibody All anti-MRE11A antibodies

Anti-MRE11A Antibody EPR3471

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307205
  • Rabbit monoclonal antibody against MRE11(clone EPR3471)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417199) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for MRE11A (NM_005591)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MRE11 was used as an immunogen.
Clone NameEPR3471 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
Predicted MW Explanation 81 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 1
Alternative NameATLD; HNGS1; MRE11; MRE11B
Database LinkNP_005582
Entrez Gene 4361 Human
Entrez Gene 17535 Mouse
Entrez Gene 64046 Rat
FunctionMRE11 is a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, MRE11 promotes the joining of noncomplementary ends in vitro using short homologies near the ends of DNA fragments.
Related PathwayStem cell - PluripotencyDruggable Genome Homologous recombinationNon-homologous end-joining

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Mre11 antibody [EPR3471]; All lanes : Anti-Mre11 antibody [EPR3471] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HT-29 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 81 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mre11 antibody [EPR3471]; TA307205 at 1/50 dilution staining Mre11 in paraffin-embedded Human cervical carcinoma tissue.

 

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