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Anti-KI67 Antibody EPR3611


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Ki-67 (clone EPR3611 )
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Ki-67 was used as an immunogen.
Clone NameEPR3611 IsotypeIgG
Species ReactivityMouse, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC, IF, FC Suggested DilutionsIHC-P: Use at an assay dependent dilution; ICC/IF: 1:500 - 1:1000
Predicted MW Explanation 395 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ,IP or WB.

Reference Data

Target NameHomo sapiens marker of proliferation Ki-67 (MKI67), transcript variant 1
Alternative NameKIA; MIB-; MIB-1; PPP1R105
Database LinkNP_002408
Entrez Gene 4288 Human
Entrez Gene 17345 Mouse
FunctionKi-67 antigen is a nuclear antigen specifically associated with cell proliferation. Ki-67 is expressed in all proliferating cells which are in the active phases of the cell cycle (late G1, S, G2, and mitosis), but absent in resting cells. In G1, it is predominately localized in the perinucleolar region and also found in nuclear matrix in the later phases (1). Ki-67 is thought to be involved in the maintaining of cell proliferation, however, its exact mechanism for function is unknown. Due to the fact that Ki-67 can be used to determine the growth fraction (the proportion of the cells committed to the cell cycle), it is consider an important marker in human tumor diagnostics and prognostics (2).
Related PathwayES Cell Differentiation/IPSDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ki67 antibody [EPR3611]; TA307569 detecting Ki67 in paraffin-embedded human tonsils (1) and paraffin-embedded mouse intestine (2) by immunohistochemistry; Note nuclear staining of proliferating cells in sample 1.
Immunocytochemistry/ Immunofluorescence - Ki67 antibody [EPR3611]; TA307569 at 1/500 dilution staining Ki67 in HeLa cells by immunofluorescence.
Flow Cytometry - Ki67 antibody [EPR3611]; TA307569 at 1/30 dilution detecting Ki67 in permeabilized HeLa cells by flow cytometry. Detection utilised TA307569 (red) or a rabbit IgG (negative)(green).


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