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Anti-MELK Antibody EPR3981


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against MELK(clone EPR3981)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402376) , 20ug Explanation
100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MELK was used as an immunogen.
Clone NameEPR3981 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 1
Alternative NameHPK38
Database LinkNP_055606
Entrez Gene 9833 Human
FunctionMaternal embryonic leucine zipper kinase (MELK), a member of the CAMK Serine/Threonine protein kinase family, functions to regulate the cell cycle (1). It serves as a marker for self-renewing multipotent neural progenitors (MNP) (1). MELK interacts in a phosphorylation-dependent manner with the transcription and splicing factor NIPP1, and this interaction can inhibit spliceosome assembly during mitosis (2). An additional substrate of MELK is the zinc finger-like protein ZPR9, which binds tightly to MELK and causes its nuclear accumulation (3). It is also expressed in tissues such as the placenta, kidney, and thymus (4).
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MELK antibody [EPR3981]; All lanes : Anti-MELK antibody [EPR3981] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 75 kDa.


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