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Anti-MC1R Antibody EPR6530
Also for MC1R (NM_002386)
|A synthetic peptide corresponding to residues in human MC1R was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|WB, ASSAY, IHC
||WB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.|
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)|
|CMM5; MSH-R; SHEP2|
|MC1R is the receptor protein for melanocyte-stimulating hormone (MSH). It is a seven pass transmembrane G protein coupled receptor that controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Different variations have been identified to correlate with skin and hair color, providing evidence that MC1R is an important component in determining normal human pigment variation (1).|
Signaling by GPCR
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Western blot - Anti-MC1 Receptor antibody [EPR6530]; All lanes : Anti-MC1 Receptor antibody [EPR6530] at 1/1000 dilution.Lane 1 : A375 cell lysate.Lane 2 : Human melanoma lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
Other-Anti-MC1 Receptor antibody [EPR6530](ab125031); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1 Receptor antibody [EPR6530]; ab125031, at a 1/500 dilution, staining MC1 Receptor in paraffin embedded Human melanoma tissue by Immunohistochemistry.