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Home Antibody All anti-MC1R antibodies

Anti-MC1R Antibody EPR6530


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310678 Rabbit Monoclonal antibody against MC1R 100ul $325 In Stock
LC400853 MC1R HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MC1R was used as an immunogen.
Clone NameEPR6530 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000
BufferpH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
Alternative NameCMM5; MSH-R; SHEP2
Database LinkNP_002377
Entrez Gene 4157 Human
FunctionMC1R is the receptor protein for melanocyte-stimulating hormone (MSH). It is a seven pass transmembrane G protein coupled receptor that controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Different variations have been identified to correlate with skin and hair color, providing evidence that MC1R is an important component in determining normal human pigment variation (1).
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interactionMelanogenesis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-MC1 Receptor antibody [EPR6530]; All lanes : Anti-MC1 Receptor antibody [EPR6530] at 1/1000 dilution.Lane 1 : A375 cell lysate.Lane 2 : Human melanoma lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
Other-Anti-MC1 Receptor antibody [EPR6530](TA310678); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1 Receptor antibody [EPR6530]; TA310678, at a 1/500 dilution, staining MC1 Receptor in paraffin embedded Human melanoma tissue by Immunohistochemistry.


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