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Home Antibody All anti-MAVS antibodies

Anti-MAVS Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306400
  • Rabbit Polyclonal VISA Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412370) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for MAVS (NM_020746)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenVISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitochondrial antiviral signaling protein (MAVS), transcript variant 1
Alternative NameCARDIF; IPS-1; IPS1; VISA
Database LinkNP_065797
FunctionTwo distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Related Pathway

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WB Image
Western blot analysis of VISA in rat brain tissue lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of VISA in mouse brain tissue with VISA antibody at 2.5 ug/ml.

 

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