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Anti-MAPT Phospho Antibody EPR2605

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A phospho-specific peptide corresponding to residues surrounding Serine 404 of human Tau was used as an immunogen.
Clone Name	EPR2605	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	IHC: 1:100 - 250, WB: 1:1,000 - 2,000,
Buffer	Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2
Alternative Name	DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Database Link	NP_005901
Function	Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Related Pathway	MAPK signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of microtubule-associated protein tau (MAPT), transcript variant 2 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • MAPT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • MAPT - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • MAPT - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2 as transfection-ready DNA • Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2, mGFP tagged • Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2 , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2 as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)