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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody EPR2605

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307181
  • Rabbit monoclonal antibody against Tau Phospho (pS404) (clone EPR2605 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 404 of human Tau was used as an immunogen.
Clone NameEPR2605 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsIHC: 1:100 - 250, WB: 1:1,000 - 2,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Database LinkNP_058525
FunctionTau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Related Pathway
MAPK signaling pathway

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WB Image
Western blot - Tau (phospho S404) antibody [EPR2605]; All lanes : Anti-Tau (phospho S404) antibody [EPR2605] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate (Untreated).Lane 2 : SH-SY5Y cell lysate (Treated with Okadaic Acid and Calyculin A).Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.

 

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