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Anti-MAPT Phospho Antibody EPR2605
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Also for MAPT (NM_005910)
|A phospho-specific peptide corresponding to residues surrounding Serine 404 of human Tau was used as an immunogen.|
|Human, Mouse, Rat
||IHC: 1:100 - 250, WB: 1:1,000 - 2,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).|
MAPK signaling pathway
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Western blot analysis on SH-SY5Y cell lysates using anti-Phospho-Tau (pS404) RabMAb .
Immunohistochemical analysis of paraffin-embedded human brain tissue using Phospho-specific anti-Tau RabMAb .