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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody EPR2401Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307177
  • Rabbit monoclonal antibody against Tau Phospho (pS199)(clone EPR2401Y) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 199 of human Tau was used as immunogen. The antibody only detects Tau phosphorylated on Serine 199.
Clone NameEPR2401Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:20000
Predicted MW Explanation 79 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Database LinkNP_058525
Entrez Gene 4137 Human
Entrez Gene 17762 Mouse
Entrez Gene 29477 Rat
FunctionTau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1, 2). Tau is hyperphosphorylated at least 25 different sites in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). CDK5, GSK3 beta, and TTBK1 have been linked to phosphorylation on Ser 199, which can induce tau aggregation and inhibit tau interaction with Fyn (4,5). With up to 9 different isoforms of Tau, Ser 199 corresponds to the most popular isoform, called isoform 8.
Related PathwayDruggable Genome MAPK signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Tau (phospho S199) antibody [EPR2401Y]; All lanes : Anti-Tau (phospho S199) antibody [EPR2401Y] at 1/20000 dilution.Lane 1 : SH SY5Y cell lysate.Lane 2 : SH SY5Y cell lysate treated with alkaline phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.Observed band size : 55 kDa .

 

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