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Home Antibody All anti-JNK1 antibodies

Anti-JNK1 TRUEMAB Antibody clone 1C2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500043
  • JNK1 (MAPK8) mouse monoclonal antibody, clone 1C2
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400970) , 20ug
100ul 325 In Stock
CF500043
  • Carrier-free (BSA/glycerol-free) JNK1 mouse monoclonal antibody, clone 1C2
100ug $450 3-4 weeks
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WB(3)
IF(1)
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Also for JNK1 (NM_002750)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 (NP_002741) produced in E.coli.
Clone Nameclone 1C2 IsotypeIgG2a
Species ReactivityHuman Concentration0.15mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB 1:500~1000, IF 1:100,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1
Alternative NameJNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Database LinkNP_002741
FunctionJNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JNK1 (RC218407, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JNK1.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-JNK1 monoclonal antibody.
WB Image
JNK1 antibody ( 1C2 ) at 1:1000 + NIH/3T3 cell lysate
IF Image
Anti-JNK1 mouse monoclonal antibody (TA500043) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY JNK1(RC218407).

 

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