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Home Antibody All anti-JNK1 antibodies

Anti-JNK1 TRUEMAB Antibody Clone OTI1C2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA500043 JNK1 (MAPK8) mouse monoclonal antibody, clone OTI1C2 (formerly 1C2) 100ul $325 In Stock
LC400970 MAPK8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500043 Carrier-free (BSA/glycerol-free) JNK1 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2) 100ug $450 3-4 weeks
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WB(3)
IF(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 (NP_002741) produced in E.coli.
Clone NameClone OTI1C2 IsotypeIgG2a
Species ReactivityHuman Concentration0.2 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB 1:500~1000, IF 1:100,
Predicted MW Explanation 44.0 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1
Alternative NameJNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Database LinkNP_002741
Entrez Gene 5599 Human
FunctionJNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JNK1 (RC218407, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JNK1.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-JNK1 monoclonal antibody.
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JNK1 antibody ( 1C2 ) at 1:1000 + NIH/3T3 cell lysate
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Anti-JNK1 mouse monoclonal antibody (TA500043) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY JNK1(RC218407).
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