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Anti-MAPK14 Antibody N/A
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Also for MAPK14 (NM_001315)
|A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH.|
|Human, Monkey, Mouse, Rat, Bovine, Rabbit, Pig, Canine, Hamster, Chicken, Sheep, Guinea pig
||WB: 1:5000, IP: 1:250
|Detects a ~43kDa protein corresponding to the molecular mass of p38 on SDS PAGE immunoblots.
|Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1|
|CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A|
Entrez Gene 1432 Human
Entrez Gene 26416 Mouse
Entrez Gene 81649 Rat
|The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms . This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway . The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death . Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP . p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs . As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes .|
|Protein KinaseDruggable Genome MAPK signaling pathwayVEGF signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayT cell receptor signaling pathwayMore Pathways >> |
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Multi-blot analysis of p38 in a cell lysate from 12 human cancer cell lines using a 1:1000 dilution of the antibody