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Home Antibody All anti-MAPK14 antibodies

Anti-MAPK14 Antibody 9F12

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326349
  • Mouse monoclonal p38 alpha (MAP Kinase) Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400523) , 20ug
100µg $325 3-7 Days
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WB(1)
IF(1)
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Also for MAPK14 (NM_001315)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length recombinant protein expressed in E.coli cells.
Clone Name9F12 IsotypeIgG1
Species ReactivityHuman, Rat. Other species not yet tested. Concentration1mg/mL
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000
BufferPBS, 50% glycerol
Purification Protein G Purified
Note Detects a ~38kDa protein corresponding to the molecular mass of p38a MAPK on SDS PAGE immunoblots.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1
Alternative NameCSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Database LinkNP_001306
FunctionThe MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms . This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway . The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death . Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP . p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs . As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes .
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Multi-blot analysis of p38Alpha MAPKinase in cell lysate from 12 human cancer cell lines using a 1:1000 dilution of the antibody
IF Image
p38 MAPKinase visualized on a retinal injury model using the antibody

 

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