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Home Antibody All anti-MAP3K7 antibodies

Anti-MAP3K7 PHOSPHO Antibody EPR2863

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SKU Description Amount Price Availability*  
TA307832
  • Rabbit monoclonal antibody against MAP3K7 Phospho (pS439)(clone EPR2863) (Phospho-Specific)
100ul $325 In Stock

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WB(1)
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Also for MAP3K7 (NM_003188)
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 439 of human MAP3K7 was used as an immunogen. This antibody only detects MAP3K7 phosphorylated at Serine 439. For mouse MAP3K7, the phospho specific peptide corresponds to residues surrounding Serine 412.
Clone NameEPR2863 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:100 - 1:250
Predicted MW Explanation 67 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant A
Alternative NameMEKK7; TAK1; TGF1a
Database LinkNP_003179
Entrez Gene 6885 Human
Entrez Gene 26409 Mouse
Entrez Gene 313121 Rat
FunctionMAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and it controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, MAP3K7 forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayWnt signaling pathwayAdherens junctionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TAK1 (phospho S439) antibody [EPR2863]; All lanes : Anti-TAK1 (phospho S439) antibody [EPR2863] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate treated with transforming growth factor-beta (TGF-beta).Lysates/proteins at 10 ug per lane.Predicted band size : 67 kDa.Observed band size : 75 kDa .
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