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Home Antibody All anti-MAP2K6 antibodies

Anti-MAP2K6 Antibody EP558Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300734
  • Rabbit Monoclonal Antibody against MAP2K6 (Clone EP558Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400975) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for MAP2K6 (NM_002758)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human MKK6 was used as immunogen.
Clone NameEP558Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1: 100 250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6)
Alternative NameMAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3
Database LinkNP_002749
Entrez Gene 5608 Human
Entrez Gene 26399 Mouse
Entrez Gene 114495 Rat
FunctionMitogen-acitvated protein kinase kinase 6 (MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK6, closely related to MKK3, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MTK1 phosphorylates MKK6 on serine 207 and threonine 211 (4).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayFc epsilon RI signaling pathwayGnRH signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MKK6 antibody [EP558Y]; Anti-MEK6 antibody [EP558Y] at 1/10000 dilution + HeLa cell lysate at 10 ug.Secondary.HRP-Labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.Observed band size : 37 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MKK6 antibody [EP558Y]; Immunohistochemical analysis of paraffin-embedded human heart muscle using TA300734 at a dilution of 1/100-1/250.

 

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