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Anti-MAP2K6 Antibody EP558Y
Also for MAP2K6 (NM_002758)
|A synthetic peptide corresponding to residues in the C-term of human MKK6 was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 10,000; IHC: 1: 100 250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6)|
|MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3|
|Mitogen-acitvated protein kinase kinase 6 (MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK6, closely related to MKK3, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MTK1 phosphorylates MKK6 on serine 207 and threonine 211 (4). |
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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Western blot - MKK6 antibody [EP558Y]; Anti-MEK6 antibody [EP558Y] at 1/10000 dilution + HeLa cell lysate at 10 µg.Secondary.HRP-Labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.Observed band size : 37 kDa.
Immunohistochemistry (Paraffin-embedded sections) - MKK6 antibody [EP558Y]; Immunohistochemical analysis of paraffin-embedded human heart muscle using ab52937 at a dilution of 1/100-1/250.