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Home Antibody All anti-LPIN1 antibodies

Anti-LPIN1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301606
  • Rabbit Polyclonal Antibody against LPIN1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC407897) , 20ug Explanation
100ul $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
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Also for LPIN1 (NM_145693)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide to an internal region (within residues 500-600) of the human LPIN1 protein. [Swiss-Prot# Q14693]
Clone Name IsotypeIgG
Species Reactivityhuman, mouse Concentration1.08 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferPBS + 30% glycerol and 0.1% sodium azide
Purification peptide affinity purified

Reference Data

Target NameHomo sapiens lipin 1 (LPIN1), transcript variant 1
Alternative NamePAP1
Database LinkNP_663731
Entrez Gene 23175 Human
Entrez Gene 14245 Mouse
FunctionThe Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1alpha; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Detection of LPIN1 in 3T3 L1 lysate
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