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Home Antibody All anti-LIN28A antibodies

Anti-LIN28A Antibody EPR4640

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310658
  • Rabbit Monoclonal antibody against LIN28A
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411135) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(5)
IF(1)
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Also for LIN28A (NM_024674)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LIN28A was used as an immunogen.
Clone NameEPR4640 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens lin-28 homolog A (C. elegans) (LIN28A)
Alternative NameCSDD1; LIN-28; lin-28A; LIN28; ZCCHC1
Database LinkNP_078950
Entrez Gene 79727 Human
FunctionLIN28A, a promoter of pluripotency, is a developmentally regulated RNA binding protein, which selectively blocks the processing of pri-let-7 miRNAs in embryonic cells (1,2). One of the let-7 family members, let-7g targets and represses LIN28 through four 3'-UTR binding sites. It has been reported that LIN28/let-7 pair has the potential to act as a 'toggle switch' that balances the decision to maintain pluripotency vs. differentiation (3). LIN28 was identified as a negative regulator of miRNA biogenesis and suggested that it may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Lin28A antibody [EPR4640]; All lanes : Anti-Lin28A antibody [EPR4640] at 1/10000 dilution.Lane 1 : NCCIT cell lysate.Lane 2 : JAR cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 23 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lin28A antibody [EPR4640]; TA310658, at 1/100 dilution, staining Lin28A in paraffin-embedded Human seminoma tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lin28A antibody [EPR4640](TA310658); TA310658 showing positive staining in Glioma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lin28A antibody [EPR4640](TA310658); TA310658 showing positive staining in Dysgerminoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lin28A antibody [EPR4640](TA310658); TA310658 showing positive staining in Embryonal carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lin28A antibody [EPR4640](TA310658); TA310658 showing negative staining in Normal brain tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-Lin28A antibody [EPR4640]; TA310658, at 1/100 dilution, staining Lin28A in NCCIT cells by Immunofluorescence.

 

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