OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-LIN28 antibodies

Anti-LIN28 Antibody EPR4639

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307045
  • Rabbit monoclonal antibody against LIN28(clone EPR4639)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411135) , 20ug Explanation
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
spacer
Also for LIN28 (NM_024674)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human LIN28 was used as an immunogen.
Clone NameEPR4639 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC or IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens lin-28 homolog A (C. elegans) (LIN28A)
Alternative NameCSDD1; LIN-28; lin-28A; LIN28; ZCCHC1
Database LinkNP_078950
Entrez Gene 79727 Human
FunctionLIN28, a promoter of pluripotency, is a developmentally regulated RNA binding protein, which selectively blocks the processing of pri-let-7 miRNAs in embryonic cells (1,2). One of the let-7 family members, let-7g targets and represses LIN28 through four 3'-UTR binding sites. It has been reported that LIN28/let-7 pair has the potential to act as a 'toggle switch' that balances the decision to maintain pluripotency vs. differentiation (3). LIN28 was identified as a negative regulator of miRNA biogenesis and suggested that it may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Lin28 antibody [EPR4639]; All lanes : Anti-Lin28 antibody [EPR4639] at 1/1000 dilution.Lane 1 : JAR cell lysate.Lane 2 : NCCIT cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 23 kDa.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title