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Anti-LIN28 Antibody EPR4639
Also for LIN28 (NM_024674)
|A synthetic peptide corresponding to residues near the N-terminus of human LIN28 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC or IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for ICC or IHC-P.
|Homo sapiens lin-28 homolog A (C. elegans) (LIN28A)|
|CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1|
|LIN28, a promoter of pluripotency, is a developmentally regulated RNA binding protein, which selectively blocks the processing of pri-let-7 miRNAs in embryonic cells (1,2). One of the let-7 family members, let-7g targets and represses LIN28 through four 3'-UTR binding sites. It has been reported that LIN28/let-7 pair has the potential to act as a 'toggle switch' that balances the decision to maintain pluripotency vs. differentiation (3). LIN28 was identified as a negative regulator of miRNA biogenesis and suggested that it may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers (1).|
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Western blot - Lin28 antibody [EPR4639]; All lanes : Anti-Lin28 antibody [EPR4639] at 1/1000 dilution.Lane 1 : JAR cell lysate.Lane 2 : NCCIT cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 23 kDa.