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Home Antibody All anti-LIMK2 antibodies

Anti-LIMK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308918
  • Rabbit polyclonal antibody to LIM kinase 2 (LIM domain kinase 2)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422193) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for LIMK2 (NM_001031801)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 294 and 665 of LIM kinase 2
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB:1:500-1:3000; IHC:1:500;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens LIM domain kinase 2 (LIMK2), transcript variant 1
Alternative Name
Database LinkNP_001026971
FunctionThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related Pathway

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WB Image
Sample (30ug whole cell lysate) A:293T (anti-LIMK2 antibody diluted at 1:1000)
IHC Image
Immunohistochemical analysis of paraffin-embedded CA922 xenograft , using LIM kinase 2(anti-LIMK2 antibody) antibody at 1:500 dilution.

 

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