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Home Antibody All anti-LGI4 antibodies

Anti-LGI4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306545
  • Rabbit Polyclonal LGI4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC408340) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenLGI4 antibody was raised against a 14 amino acid peptide from near the center of human LGI4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens leucine-rich repeat LGI family, member 4 (LGI4)
Alternative NameLGIL3
Database LinkNP_644813
FunctionThe leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development. Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.
Related Pathway

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WB Image
Western blot analysis of LGI4 in human brain tissue lysate with LGI4 antibody at (A) 1 and (B) 2 µg/ml.

 

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