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Anti-LCK Antibody EP2158Y
|A synthetic phospho-peptide corresponding to residues surrounding Tyrosine 505 of human LCK was used as immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens LCK proto-oncogene, Src family tyrosine kinase (LCK), transcript variant 2|
|IMD22; LSK; p56lck; pp58lck; YT16|
|The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4). |
Delta-Notch Signaling Pathway
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Western blot - Lck (phospho Y505) antibody [EP2158Y]; All lanes : Anti-Lck (phospho Y505) antibody [EP2158Y] at 1/10000 dilution.Lane 1 : Jurkat cell lysates, untreated .Lane 2 : Jurkat cell lysates, treated with AP .Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 58 kDa.Observed band size : 58 kDa.Additional bands at : 61 kDa (possible isoform).