Home Antibody All anti-Klra2 antibodies
Also for Klra2 (NM_008462)
|KLRA2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of mouse KLRA2.|
||ELISA, WB: 0.5 - 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Mus musculus killer cell lectin-like receptor, subfamily A, member 2 (Klra2), transcript variant 2|
|KLRA2 (also known as Ly49B) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA2 is thought to be an inhibitory receptor and associates with the protein tyrosine phosphatases SHP1, SHP2, and SHIP in transfected cells. This antibody is predicted to not cross-react with other LY49 receptors.|
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Western blot analysis of KLRA2 in mouse spleen tissue lysate with KLRA2 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of KLRA2 in mouse spleen tissue with KLRA2 antibody at 2.5 ug/mL.