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Home Antibody All anti-KRT8 antibodies

Anti-KRT8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300826
  • Rabbit Polyclonal Antibody against KRT8
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419425) , 20ug
100ul $379 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for KRT8 (NM_002273)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus of human CK-8 was used as an immunogen.
Clone Name IsotypeImmunogen affinity purified
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500; IP: 1:60; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens keratin 8 (KRT8), transcript variant 2
Alternative NameCARD2; CK-8; CK8; CYK8; K2C8; K8; KO
Database LinkNP_002264
FunctionKeratins, the intermediate filament proteins of epithelial cells, connect to desmosomes, the cell-cell adhesion structures at the surface membrane. Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, and can also be synthesized in certain non-epithelial cells (1). Keratin 8 and 18 (CK8/18) are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine (2). While K8/K18 are essential for maintaining structural integrity, there is accumulating evidence indicating that they also exert non-mechanical functions. It has been reported that K8/K18-free hepatocytes from K8-null mice are more sensitive to Fas-mediated apoptosis, in line with an increased Fas density at the cell surface and an altered c-Flip regulation of the anti-apoptotic ERK1/2 signaling pathway (3).
Related Pathway
EGFR1 Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Cytokeratin 8 antibody; Anti-Cytokeratin 8 antibody at 1/500 dilution + HeLa cell lysate at 10 µg.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 54 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Cytokeratin 8 antibody; TA300826 at 1/100 dilution staining Cytokeratin 8 in human gastric adenocarcinoma by Immunohistochemistry, Paraffin embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Cytokeratin 8 antibody; TA300826 at 1/100 dilution staining Cytokeratin 8 in HeLa cells by Immunofluorescence.

 

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