Home Antibody All anti-KPNA2 antibodies
Anti-KPNA2 Antibody Polyclonal
Also for KPNA2 (NM_002266)
|KPNA2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA2.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|KPNA2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|KPNA2 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)|
|IPOA1; QIP2; RCH1; SRP1alpha|
|KPNA2 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.|
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Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of KPNA2 in human heart tissue with KPNA2 antibody at 5 ug/mL.