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Home Antibody All anti-KPNA2 antibodies

Anti-KPNA2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308727
  • Rabbit polyclonal antibody to karyopherin alpha 2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419418) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for KPNA2 (NM_002266)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 468 and 529 of KPNA2 (Uniprot ID#P52292)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Rhesus Monkey, Chimpanzee) Concentration0.71mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 58kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (100%), Rat (100%), Rhesus Monkey (92%), Chimpanzee (100%)

Reference Data

Target NameHomo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
Alternative NameIPOA1; QIP2; RCH1; SRP1alpha
Database LinkNP_002257
Entrez Gene 3838 Human
Entrez Gene 16647 Mouse
Entrez Gene 85245 Rat
Entrez Gene 100430009 Monkey
FunctionThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]
Related PathwayStem cell - PluripotencyDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample(30 ug of whole cell lysate). A:HeLa S3. B:Hep G2. C:MOLT4. 10% SDS PAGE. TA308727 diluted at 1:500
IF Image
karyopherin alpha 2 antibody [C3], C-term detects karyopherin alpha 2 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in ice-cold MeOH for 5 min. Green: karyopherin alpha 2 protein stained by karyopherin alpha

 

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