Home Antibody All anti-KPNA2 antibodies
Also for KPNA2 (NM_002266)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 468 and 529 of karyopherin alpha 2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)|
|IPOA1; QIP2; RCH1; SRP1alpha|
|The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]|
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Sample(30 ug of whole cell lysate) A:HeLa S3 B:HepG2 C:MOLT4 (anti-KPNA2 antibody diluted at 1:500)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using karyopherin alpha 2(anti-KPNA2 antibody) antibody at 1:200 dilution.