Home Antibody All anti-KLRA1 antibodies
Also for KLRA1 (NM_006611)
|KLRA1 antibody was raised against a 13 amino acid peptide near the carboxy terminus of human KLRA1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens killer cell lectin-like receptor subfamily A, member 1 (KLRA1)|
|KLRA#; Ly-49L; Ly49; LY49L; MGC126520; MGC126522;class I MHC receptor KLRA22; Klra22; A1; Ly49a; Ly49o; Ly49v; OTTMUSP00000026268; natural killer cell receptor Ly49A; killer cell lectin-like receptor, subfamily A, member 1|
|KLRA1 (also known and Ly49L) is a member of the LY49 family of receptors Natural killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. At least three isoforms of KLRA1 are known to exist.|
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Western blot analysis of KLRA1 in 293 cell lysate with KLRA1 antibody at (A) 1 ug/ml and (B) 2 ug/ml.
Immunohistochemistry of KLRA1 in human spleen tissue with KLRA1 antibody at 2.5 ug/ml.