Home Antibody All anti-KLF4 antibodies
Also for KLF4 (NM_004235)
|KLF4 antibody was raised against a 20 amino acid peptide near the carboxy terminus of human KLF4.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens Kruppel-like factor 4 (gut) (KLF4)|
Entrez Gene 9314 Human
Entrez Gene 16600 Mouse
Entrez Gene 114505 Rat
|KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.|
|ES Cell Differentiation/IPSAdult stem cellsEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors |
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Western blot analysis of KLF4 in human liver tissue lysate with KLF4 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of KLF4 in rat liver tissue with KLF4 antibody at 5 ug/mL.