Home Antibody All anti-KISS1 antibodies
Anti-KISS1 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for KISS1 (NM_002256)
|DNA immunization. This antibody was made against a protein fragment from the entire range of the protein.|
||ELISA: 1:100-1:2000; IHC: 1:450; IF: 1:112
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens KiSS-1 metastasis-suppressor (KISS1)|
|KiSS-1 gene encodes metastin, also known as kisspeptin or KiSS-1 peptide, which binds to a G protein-coupled receptor GPR54. KiSS-1 is dominantly expressed in brain (e.g. anteroventral periventricular nucleus, AVPV arcuate nucleus, ARC), placenta, and pancreas, etc. Metastin plays an important role in regulating the GnRH secretion in brain and MMP-9 expression in placenta, which is associated with development of puberty and sex maturation (e.g. Idiopathic hypogonadotropic hypogonadism, IHH) as well as placentation (e.g. pre-eclampsia), respectively. Metastin was originally discovered as a tumor metastasis suppressor (e.g. melanoma, breastcancer).|
Signaling by GPCR
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Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblasts.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-251 MG shows positivity in nucleoli & cytoplasm.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.