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Home Antibody All anti-KDM4A antibodies

Anti-KDM4A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306831
  • Rabbit Polyclonal JMJD2A Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402370) , 20ug
100ug $325 In Stock
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WB(1)
IHC(1)
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Also for KDM4A (NM_014663)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenJMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 4A (KDM4A)
Alternative NameJHDM3A; JMJD2; JMJD2A; TDRD14A
Database LinkNP_055478
FunctionMembers of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.
Related Pathway

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WB Image
Western blot analysis of JMJD2A in rat liver tissue lysate with JMJD2A antibody at (A) 1 and (B) 2 µg/ml.
IHC Image
Immunohistochemistry of JMJD2A in rat liver tissue with JMJD2A antibody at 5 ug/ml.

 

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