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Anti-KDM1 Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	LSD1 antibody was raised against a 16 amino acid peptide from near the center of human LSD1.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1 - 2 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens lysine (K)-specific demethylase 1A (KDM1A), transcript variant 1
Alternative Name	AOF2; BHC110; KDM1; LSD1
Database Link	NP_001009999
Function	Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • KDM1A - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • KDM1A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Kdm1a - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • KDM1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Aof2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens lysine (K)-specific demethylase 1A (KDM1A), transcript variant 1 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens lysine (K)-specific demethylase 1A (KDM1A), transcript variant 1 as transfection-ready DNA Related cDNA Clones • Homo sapiens lysine (K)-specific demethylase 1A (KDM1A), transcript variant 1 as transfection-ready DNA • Homo sapiens lysine (K)-specific demethylase 1A (KDM1A) transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)