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Home Antibody All anti-KDM1 antibodies

Anti-KDM1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306302
  • Rabbit Polyclonal LSD1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC433555) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for KDM1 (NM_001009999)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLSD1 antibody was raised against a 16 amino acid peptide from near the center of human LSD1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 1A (KDM1A), transcript variant 1
Alternative NameAOF2; BHC110; KDM1; LSD1
Database LinkNP_001009999
Entrez Gene 23028 Human
Entrez Gene 99982 Mouse
Entrez Gene 500569 Rat
FunctionHistone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of LSD1 in P815 cell lysate with LSD1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of LSD1 in human small intestine tissue with LSD1 antibody at 2 ug/ml.

 

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