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Home Antibody All anti-JMJD5 antibodies

Anti-JMJD5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302115
  • Rabbit Polyclonal Antibody against JMJD5 (C-term)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403027) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for JMJD5 (NM_024773)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human JMJD5.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman, Mouse Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:250~500; IHC: 1: 10~50; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 8 (KDM8), transcript variant 2
Alternative NameJMJD5
Database LinkNP_079049
FunctionCovalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of anti-JMJD5 (C-term) Pab pre-incubated with and without blocking peptide (BP1031b) in mouse liver tissue lysate. JMJD5 (C-term)(arrow) was detected using the purified Pab.</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>
IHC Image
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with JMJD5 (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>

 

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