OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-Insig1 antibodies

Anti-Insig1 Antibody

div

Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA318983
  • Rabbit polyclonal anti-Insig1 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC405025) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

spacer
WB(1)

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 248 of rat Insig1
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat, bovine, hamster Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml
Buffer100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens insulin induced gene 1 (INSIG1), transcript variant 2
Alternative NameCL-6; CL6
Database LinkNP_938150
Entrez Gene 3638 Human
Entrez Gene 231070 Mouse
Entrez Gene 64194 Rat
FunctionInsulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of InSig1 expression in Jurkat cell lysate.
spacer

 

spacer
Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title