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Home Antibody All anti-Insig1 antibodies

Anti-Insig1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA318983 Rabbit polyclonal anti-Insig1 antibody 100ug $325 3-7 Days
LC405025 INSIG1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 248 of rat Insig1
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat, bovine, hamster Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml
Buffer100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens insulin induced gene 1 (INSIG1), transcript variant 2
Alternative NameCL-6; CL6
Database LinkNP_938150
Entrez Gene 3638 Human
Entrez Gene 231070 Mouse
Entrez Gene 64194 Rat
FunctionInsulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of InSig1 expression in Jurkat cell lysate.


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