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Home Antibody All anti-Ido1 antibodies

Anti-Ido1 Antibody 10.1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319542
  • Mouse monoclonal anti-IDO1 antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400784) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for Ido1 (NM_002164)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenAnti-IDO1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with fragment of recombinant human and mouse IDO1 protein followed by hybridoma development.
Clone Name10.1 Isotype
Species Reactivityhuman, mouse Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:5000-1:50000, WB: 1:500-1:1500, IHC: 1:100-1:500, IF: 1:50-1:100, IP: 10-100 uL
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.

Reference Data

Target NameHomo sapiens indoleamine 2,3-dioxygenase 1 (IDO1)
Alternative NameIDO; IDO-1; INDO
Database LinkNP_002155
Function
Related Pathway

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WB Image
Western Blot of Mouse Anti-IDO1 Antibody. Lane 1: untreated HeLa cells. Lane 2: IFN-r treated HeLa cells. Load: 35 µg per lane. Primary antibody: IDO 1 Antibody at 1:1000 for overnight at 4°C. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 41-42 kDa, 41-42 kDa for IDO-1. Other band(s): none.

 

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