Home Antibody All anti-ITK antibodies
|A synthetic peptide corresponding to residues near the C-term of human Emtk/Itk/Tsk was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500~1000; IHC: 1:50-100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Homo sapiens IL2-inducible T-cell kinase (ITK)|
|EMT; LPFS1; LYK; PSCTK2|
|Emtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells (1). Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains (2). It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs (3). Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28 (4). |
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Western blot - ITK antibody; All lanes : Anti-ITK antibody at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : A431 cell lysate.Predicted band size : 72 kDa.Observed band size : 68 kDa .
Immunohistochemistry (Paraffin-embedded sections) - ITK antibody; Ab32113, at a 1/50 dilution, staining ITK in paraffin embedded normal lymph node tissue by Immunohistochemistry.