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Home Antibody All anti-ITK antibodies

Anti-ITK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300509
  • Rabbit Polyclonal Antibody against ITK
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401706) , 20ug
100ul $379 3-7 Days
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WB(1)
IHC(1)
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Also for ITK (NM_005546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-term of human Emtk/Itk/Tsk was used as immunogen.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500~1000; IHC: 1:50-100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified

Reference Data

Target NameHomo sapiens IL2-inducible T-cell kinase (ITK)
Alternative NameEMT; LPFS1; LYK; PSCTK2
Database LinkNP_005537
FunctionEmtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells (1). Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains (2). It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs (3). Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28 (4).
Related Pathway

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WB Image
Western blot - ITK antibody; All lanes : Anti-ITK antibody at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : A431 cell lysate.Predicted band size : 72 kDa.Observed band size : 68 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - ITK antibody; Ab32113, at a 1/50 dilution, staining ITK in paraffin embedded normal lymph node tissue by Immunohistochemistry.

 

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