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Anti-ITGAV Antibody EPR5583
Also for ITGAV (NM_001144999)
|A synthetic peptide corresponding to residues in the intracellular domain of human CD51 / Integrin alpha-V was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, Assay, FC
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
|86, 116 kDa
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens integrin, alpha V (ITGAV), transcript variant 2|
|CD51; MSK8; VNRA; VTNR|
Entrez Gene 3685 Human
Entrez Gene 16410 Mouse
Entrez Gene 296456 Rat
|Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing CD51 / Integrin alpha-V undergoes post-translational cleavage to yield disulfide-linked heavy chain (125 kDa) and light chain (25 kDa), which combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the CD51 / Integrin alpha-V, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction (1). |
|ES Cell Differentiation/IPSTransmembraneDruggable Genome Focal adhesionECM-receptor interactionCell adhesion molecules (CAMs)Regulation of actin cytoskeletonPathways in cancerSmall cell lung cancerMore Pathways >> |
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Western blot - Anti-Integrin alpha V + beta 6 antibody [EPR5583]; All lanes : Anti-Integrin alpha V + beta 6 antibody [EPR5583] at 1/1000 dilution.Lane 1 : A549 cell lysates.Lane 2 : A431 cell lysates.Lane 3 : C6 cell lysates.Lane 4 : RAW264.7 cell lysates.Lane 5 : PC12 cell lysates.Lane 6 : NIH 3T3 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 86, 116 kDa.
Other-Anti-Integrin alpha V + beta 6 antibody [EPR5583](TA310958); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-Integrin alpha V + beta 6 antibody [EPR5583]; TA310958 at 1/10 dilution staining Integrin alpha V + beta 6 in permeabilized A549 cells by Flow cytometry (red) or a rabbit IgG (negative) (green).