Home All anti-ITGAV antibodies
Anti-ITGAV Antibody EPR5583
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ITGAV (NM_001144999)
|A synthetic peptide corresponding to residues in the intracellular domain of human CD51 / Integrin alpha-V was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IP: 1:10 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens integrin, alpha V (ITGAV), transcript variant 2|
|CD51; MSK8; VNRA; VTNR|
|Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing CD51 / Integrin alpha-V undergoes post-translational cleavage to yield disulfide-linked heavy chain (125 kDa) and light chain (25 kDa), which combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the CD51 / Integrin alpha-V, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction (1). |
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Western blot analysis on (A) A549, (B) A431, (C) C6, (D) RAW264.7, (E) PC-12, and (F) NIH/3T3 cell lysates using anti-CD51 / Integrin alpha-V RabMAb.
Flow cytometric analysis of permeabilized A549 cells using anti-CD51 / Integrin alpha-V RabMAb (red) or a rabbit IgG (negative) (green).