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Home Antibody All anti-ISG15 antibodies

Anti-ISG15 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302035
  • Rabbit Polyclonal Antibody against ISG15 (Center R87)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417516) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for ISG15 (NM_005101)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human ISG15.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:50~100; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens ISG15 ubiquitin-like modifier (ISG15)
Alternative NameG1P2; hUCRP; IFI15; IP17; UCRP
Database LinkNP_005092
FunctionISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.
Related Pathway

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WB Image
Western blot analysis of ISG15(arrow) using rabbit polyclonal ISG15 Antibody (Center R87) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with ISG15 gene (Lane 2) (Origene Technologies).

 

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