Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens interferon regulatory factor 9 (IRF9)
Synonyms:
IRF-9; ISGF3; ISGF3G; p48
Immunogen
A synthetic peptide corresponding to residues in human IRF9 was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
IRF9, or Interferon regulatory factor 9, is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STAT’s then dimerize, associate with IRF9/ISGF3G to form a complex called ISGF3 transcription factor, which enters the nucleus. Moreover, IRF9 is translocated into the nucleus upon activation by IFN-alpha/beta (1).
Related Pathway
Jak-STAT signaling pathway
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Western blot analysis on (A) K562 treated with IFN-alpha, (B) K562, (C) HeLa treated with IFN-alpha, (D) HeLa, and (E) Jurkat cell lysates using anti-IRF9 RabMAb .
