Anti-IRF4 Antibody, EPR5653

Also for IRF4 (NM_002460)

Gene Name	Homo sapiens interferon regulatory factor 4 (IRF4), transcript variant 1
Synonyms:	LSIRF; MUM1; NF-EM5
Immunogen	A synthetic peptide corresponding to residues on the N-terminus in human IRF-4 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5653	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:10,000 - 50,000; IHC 1:100 - 250; IP: 1:10 - 100;
Background	IRF-4 belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by viruses and the regulation of interferon-inducible proteins.IRF-4 is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A mutation in IRF-4 may be a cause of multiple myeloma (1).
Related Pathway	Apoptosis

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WB Image

Western blot analysis on (A) Ramos, (B) HuT-78, and (C) IM-9 cell lysates using anti-IRF-4 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-IRF-4 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IRF-4 RabMAb.

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Anti-IRF4 Antibody EPR5653

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