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Home Antibody All anti-IRF3 antibodies

Anti-IRF3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306191
  • Rabbit Polyclonal IRF8 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400600) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for IRF3 (NM_001571)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interferon regulatory factor 3 (IRF3), transcript variant 1
Alternative NameMGC94729; interferon regulatory factor 3
Database LinkNP_001562
FunctionInterferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases (2,3), but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells (4,5). Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia (6).
Related Pathway
Apoptosis
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 antibody at 1µg/ml in (A) the presence and (B) absence of blocking peptide.

 

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