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Home Antibody All anti-IRAK3 antibodies

Anti-IRAK3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306061
  • Rabbit Polyclonal IRAK-M Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for IRAK3 (NM_007199)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenIRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1
Alternative NameASRT5; IRAKM
Database LinkNP_009130
Entrez Gene 11213 Human
Entrez Gene 73914 Mouse
Entrez Gene 314870 Rat
FunctionInterleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
Related PathwayProtein KinaseDruggable Genome ApoptosisNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IRAK-M in mouse spleen (M) and rat liver (R) tissue lysates with IRAK-M antibody at 1 ug/ml.
IHC Image
Immunohistochemical staining of rat liver cells using IRAK-M antibody at 2 ug/ml.

 

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