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Anti-IRAK3 Antibody Y278
Also for IRAK3 (NM_007199)
|A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1,000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1|
|IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5). |
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Western blot - IRAK3 antibody [Y278]; Anti-IRAKM antibody [Y278] at 1/20000 dilution + A431 cell lysate.Predicted band size : 68 kDa.Observed band size : 68 kDa.