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Anti-IRAK3 Antibody Y278


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against IRAK3 (Clone Y278)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402105) , 20ug Explanation
100ul $325 3-7 Days
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Also for IRAK3 (NM_007199)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen.
Clone NameY278 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1,000; IP: 1:50
Predicted MW Explanation 68 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1
Alternative NameASRT5; IRAKM
Database LinkNP_009130
Entrez Gene 11213 Human
FunctionIRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).
Related PathwayProtein KinaseDruggable Genome ApoptosisNeurotrophin signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - IRAK3 antibody [Y278]; Anti-IRAKM antibody [Y278] at 1/20000 dilution + A431 cell lysate.Predicted band size : 68 kDa.Observed band size : 68 kDa.


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