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Home Antibody All anti-INSR antibodies
UltraMAB

Anti-INSR GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590751
  • Rabbit Polyclonal Insulin Receptor Antibody
100ug 325 In Stock
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ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman , Dog Concentration1.09mg/ml
Guaranteed Application *ELISA Suggested Dilutions WB 1:5000~20000,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens insulin receptor (INSR), transcript variant 2
Alternative NameCD220; HHF5
Database LinkNP_001073285
Entrez Gene 3643 Human
Entrez Gene 484990 Dog
FunctionThe insulin receptor is an essential protein present on the surface of virtually all cells. Little is known about the control of the level of this protein on cellular surfaces, but it has been found that the level of insulin receptor protein correlates roughly with the level of insulin receptor (IR) gene transcripts within cells (1). The insulin receptor plays a critical role in the maintenance of glucose homeostasis. Regulation of this key function must be under stringent controls (2). Insulin receptor substrate 1 (IRS-1) and src homology and collagen protein (SHC) are signaling proteins which are rapidly phosphorylated on tyrosines after insulin receptor activation. It has been shown that both SHC and IRS-1 interact with the tyrosine-phosphorylated NPEY motif of the IR and insulin-like growth factor I receptor via non-SH2 domains (3).
Related PathwayProtein KinaseTransmembraneDruggable Genome Adherens junctionInsulin signaling pathwayType II diabetes mellitus

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* OriGene provides validated application data and protocol, with money back guarantee.

ELISA Image
ELISA: Insulin Receptor Antibody

 

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