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Home Antibody All anti-INSIG1 antibodies

Anti-INSIG1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301693 Rabbit Polyclonal Antibody against Insig1 100ul $325 3-7 Days
LC417235 INSIG1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503.
Clone Name IsotypeIgG
Species Reactivityhuman Concentration1.02 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferPBS + 30% glycerol and 0.1% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens insulin induced gene 1 (INSIG1), transcript variant 1
Alternative NameCL-6; CL6
Database LinkNP_005533
Entrez Gene 3638 Human
FunctionOxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Related PathwayTransmembraneDruggable Genome

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WB Image
Detection of Insig 1 in HepG2 lyaste


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